ESTRÉS CELULAR Y EDAD

Grupo BIO-184

LÍNEAS DE INVESTIGACIÓN

Hydroxytyrosol in cerebral ischemia: a study through the brain proteome and microbiota. Ángela Naranjo, Magdalena Martínez Cañamero, Mª del Mar Muñoz, Santos Blanco, Raquel Hernández, Esther Martínez-Lara, Eva Siles. (2026). Journal of Ethnopharmacology, enviado.

Frequency-dependent diffusion tensor distribution imaging in the evaluation of ischemic stroke. Gröhn S, Naranjo Á, Narváez O, Yon M, Buz-Yalug B, Blanco S, Topgaard D, Martínez-Lara E, Peinado MÁ, Tohka J, Sierra A. (2026). Neuroscience Informatics, 6(2), 100270. 

https://doi.org/10.1016/j.neuri.2026.100270

Does Neuroglobin Protect Against Stroke? Insights Into the Role of Neurovascular Unit Cells. Peinado MÁ, Blanco S, Naranjo Á, Muñoz-Gallardo MM, Siles E, Hernández R, Gröhn S, Sierra A, Martínez-Lara E. (2026). Cellular and Molecular Neurobiology, 46(1), 23. 

https://doi.org/10.1007/s10571-025-01656-9

Skin temperature and nitric oxide in premenopausal and postmenopausal women with fibromyalgia. Rus A, Coca-Guzmán B, Casas-Barragán A, Molina F, Correa-Rodríguez M, Aguilar-Ferrándiz ME.. (2025). Climacteric, 28(2), 133-142.

https://doi.org/10.1080/13697137.2025.2465294

Effect of menopause on circulating amino acid concentrations in women with fibromyalgia and healthy women. Rus A, Coca-Guzmán B, Molina F, Correa-Rodríguez M, Martínez-Martos JM, Ramírez-Expósito MJ, Aguilar-Ferrándiz ME.. (2025). Maturitas, 193, 108171.

https://doi.org/10.1016/j.maturitas.2024.108171

Nitric oxide synthase system in the brain development of neonatal hypothyroid rats. López-Ramos JC, Martínez-Lara E, Serrano J, Fernández P, Parras GG, Ruiz-Marcos A, Rodrigo J. (2025). Neuroscience, 565, 155-171.

https://doi.org/10.1016/j.neuroscience.2024.10.040

The Interplay Between Melatonin and Nitric Oxide: Mechanisms and Implications in Stroke Pathophysiology. Blanco S, Muñoz-Gallardo MM, Hernández R, Peinado MÁ. (2025). Antioxidants, 14(6), 724. 

https://doi.org/10.3390/antiox14060724

Different Correlation Patterns Between Circulating Amino Acids and Body Temperature in Fibromyalgia Syndrome: A Cross-Sectional Study. Casas-Barragán A, Molina F, Tapia-Haro RM, Martínez-Martos JM, Ramírez-Expósito MJ, Rus A, Correa-Rodríguez M, Aguilar-Ferrándiz ME. (2024). Int J Mol Sci, 25(24), 13517.

https://doi.org/10.3390/ijms252413517

Nutraceutical Supplementation as a Potential Non-Drug Treatment for Fibromyalgia: Effects on Lipid Profile, Oxidative Status, and Quality of Life. de la Cruz S, Blanco S, Rus A, Molina-Ortega FJ, Ocaña E, Hernández R, Visioli F, del Moral ML (2024). International Journal of Molecular Sciences, 25(18), 9935. 

https://doi.org/10.3390/ijms25189935

Hydroxytyrosol, a Promising Supplement in the Management of Human Stroke: An Exploratory Study. International journal of molecular sciences. Naranjo, Á., Álvarez-Soria, MJ, Aranda-Villalobos, P., Martínez-Rodríguez, AM, Martínez-Lara, E., & Siles, E. (2024). International journal of molecular sciences, 25 (9), 4799.

https://doi.org/10.3390/ijms25094799

Predictive Ability of Serum Amino Acid Levels to Differentiate Fibromyalgia Patients from Healthy Subjects. Rus , A., López-Sánchez, JA, Martínez-Martos, JM, Ramírez-Expósito, MJ, Molina, F., Correa-Rodríguez, M. & Eagle-Ferrands, ME (2024).  Diagnóstico y terapia molecular28 (1), 113-128.

 https://doi.org/10.1007/s40291-023-00677-8

Vasodilatory Peripheral Response and Pain Levels following Radiofrequency Stressor Application in Women with Fibromyalgia. Casas-Barragán, A., Muñoz-Revilla, A., Tapia-Haro, RM, Molina, F., Correa-Rodríguez, M., & Aguilar-Ferrandiz, ME (2024). Biomedicines12 (1), 142.

https://doi.org/10.3390/biomedicines12010142

Do routine laboratory parameters have predictive ability to differentiate subjects with Fibromyalgia from healthy subjects?. Rus A, Molina F, Camacho MV, La Rubia M, Aguilar-Ferrándiz ME, del Moral ML. (2023). Clin Nurs Res, 32 (1), 6-14.

https://doi.org/10.1177/10547738221126003

Calcitonin Gene-Related Peptide, Vascular Endothelial Growth Factor, and Clinical Manifestations in Women With Fibromyalgia. Rus, A., López-Sánchez, J. A., García-Ríos, M. C., Tapia-Haro, R. M., Casas-Barragán, A., Correa-Rodríguez, M., & Aguilar-Ferrándiz, M. E. (2023). Nursing research72 (1), E1–E7.

https://doi.org/10.1097/NNR.0000000000000622

Associations among serum VEGF and CGRP levels with the peripheral vascular blood flow of the skin of the hands in women with Fibromyalgia.Casas-Barragán, A., García-Ríos, M. C., Rus, A., Tapia-Haro, R. M., Correa-Rodríguez, M., & Aguilar-Ferrándiz, M. E. (2023). Journal of thermal biology112, 103469.

https://doi.org/10.1016/j.jtherbio.2023.103469

Serum VEGF and CGRP Biomarkers: Relationships with Pain Intensity, Electric Pain, Pressure Pain Threshold, and Clinical Symptoms in Fibromyalgia-An Observational Study. Tapia-Haro, RM, Molina, F., Rus, A., Casas-Barragán, A., Correa-Rodríguez, M. y Aguilar-Ferrándiz, ME (2023). International journal of molecular sciences24(21), 15533.

https://doi.org/10.3390/ijms242115533

 Tyrosol: Repercussion of the Lack of a Hydroxyl-Group in the Response of MCF-7 Cells to Hypoxia.  Calahorra, J., Araujo-Abad, S., Granadino-Roldán, JM, Naranjo, Á., Martínez-Lara, E., & Siles, E. (2023).Journal of medicinal food26(7), 511–520.

https://doi.org/10.1089/jmf.2022.0096

Influence of the hydrodynamic size and ζ potential of manganese ferrite nanozymes as peroxidase-mimicking catalysts at pH 4 in different buffers.  Moreno‐Castilla C, Naranjo Á, López‐Ramón MV, Siles E, López‐Peñalver JJ, De Almodóvar JMR. (2022). Revista de Catálisis, 414, 179-185.

https://doi.org/10.1016/j.jcat.2022.09.010 

New Strategies for Stroke Therapy: Nanoencapsulated Neuroglobin. . Blanco, S., Martínez-Lara, E., Siles, E., & Peinado, M. Á. (2022). Pharmaceutics14 (8), 1737.

https://doi.org/10.3390/pharmaceutics14081737

Biological Implications of a Stroke Therapy Based in Neuroglobin Hyaluronate Nanoparticles. Neuroprotective Role and Molecular Bases.  Peinado, M. Á., Ovelleiro, D., Del Moral, ML, Hernández, R., Martínez-Lara, E., Siles, E., Pedrajas, JR, García-Martín, ML, Caro, C., Peralta , S., Morales, M.E., Ruiz, M.A., & Blanco, S. (2021).International journal of molecular sciences23 (1), 247.

https://doi.org/10.3390/ijms23010247

Effects of Erythrodiol on the Antioxidant Response and Proteome of HepG2 Cells. Peñas-Fuentes, J. L., Siles, E., Rufino-Palomares, E. E., Pérez-Jiménez, A., Reyes-Zurita, F. J., Lupiáñez, J. A., Fuentes-Almagro, C., & Peragón-Sánchez, J. (2021). Antioxidants (Basel, Switzerland)11(1), 73.

https://doi.org/10.3390/antiox11010073

Dietary Intake Assessment, Severity of Symptoms, and Pain in Women with Fibromyalgia. Correa-Rodríguez, M., Rueda-Medina, B., Casas-Barragán, A., Tapia-Haro, RM, Molina, F., & Aguilar-Ferrándiz, ME (2021). Clinical nursing research,30 (8), 1164–1173.

https://doi.org/10.1177/10547738211012464

Misperception of Visual Vertical in Peripheral Vestibular Disorders. A Systematic Review With Meta-Analysis. Gaitán, E., Molina, F., Montilla-Ibáñez, MD, Del-Pino-Casado, R., Rodríguez-Almagro, D., y Lomas-Vega, R. (2021). The Laryngoscope131(5), 1110–1121.

https://doi.org/10.1002/lary.29124

Association of core body temperature and peripheral blood flow of the hands with pain intensity, pressure pain hypersensitivity, central sensitization, and fibromyalgia symptoms. Casas-Barragán, A., Molina, F., Tapia-Haro, RM, García-Ríos, MC, Correa-Rodríguez, M., y Aguilar-Ferrándiz, ME (2021). Therapeutic advances in chronic disease12, 2040622321997253. 

https://doi.org/10.1177/2040622321997253

Evaluation of sympathetic adrenergic branch of cutaneous neural control throughout thermography and its relationship to nitric oxide levels in patients with fibromyalgia. Aguilar-Ferrándiz, ME, Casas-Barragán, A., Tapia-Haro, RM, Rus, A., Molina, F., & Correa-Rodríguez, M. (2021). Journal of thermal biology95 , 102813.

 https://doi.org/10.1016/j.jtherbio.2020.102813

Utilidad de la primera analítica de Urgencias realizada en pacientes con COVID-19 como predictora de mortalidad (PMCOVID SCORE) [Usefulness of COVID-19 patients first analysis made at the Emergency Department as a prediction tool for mortality (PMCovid Score).].García-Ruano, A. B., García-Chileme, S., Martínez-Chamorro, A., Martínez-Lara, E., & Coca-Zúñiga, R. (2021). Revista Española de Salud Pública95, e202110144.

Adrenomedullin Is a Diagnostic and Prognostic Biomarker for Acute Intracerebral Hemorrhage. Julián-Villaverde, F. J., Ochoa-Callejero, L., Siles, E., Martínez-Lara, E., & Martínez, A. (2021). Current issues in molecular biology43(1), 324–334.

https://doi.org/10.3390/cimb43010027

Influence of Oxidative Stress-Related Genes on Susceptibility to Fibromyalgia.Rus, A., Robles-Fernandez, I., Martinez-Gonzalez, L. J., Carmona, R., & Alvarez-Cubero, M. J. (2021).Nursing research70(1), 44–50.

https://doi.org/10.1097/NNR.0000000000000480

Lipid nanoparticles for the transport of drugs like dopamine through the blood–brain barrier.Ortega E, Blanco S, Ruiz A, Peinado MÁ, Peralta S, Morales ME. (2021). J Nanopart, 106.

https://doi.org/10.1007/s11051-021-05218-0

Impact of hydroxytyrosol on stroke: tracking therapy response on neuroinflammation and cerebrovascular parameters using PET-MR imaging and on functional outcomes. Barca, C., Wiesmann, M., Calahorra, J., Wachsmuth, L., Döring, C., Foray, C., Heiradi, A., Hermann, S., Peinado, M. Á., Siles, E., Faber, C., Schäfers, M., Kiliaan, A. J., Jacobs, A. H., & Zinnhardt, B. (2021). Theranostics11(9), 4030–4049.

https://doi.org/10.7150/thno.48110

Associations Among Nitric Oxide and Enkephalinases With Fibromyalgia Symptoms. Aguilar-Ferrándiz, M. E., Casas-Barragán, A., Rus, A., Tapia-Haro, R. M., Martínez-Martos, J. M., Molina, F., & Correa-Rodríguez, M. (2021).Nursing research70(2), E11–E20.

https://doi.org/10.1097/NNR.0000000000000496

Evaluation of sympathetic adrenergic branch of cutaneous neural control throughout thermography and its relationship to nitric oxide levels in patients with fibromyalgia.Aguilar-Ferrándiz, M. E., Casas-Barragán, A., Tapia-Haro, R. M., Rus, A., Molina, F., & Correa-Rodríguez, M. (2021). Journal of thermal biology95, 102813.

https://doi.org/10.1016/j.jtherbio.2020.102813

Hyaluronate Nanoparticles as a Delivery System to Carry Neuroglobin to the Brain after Stroke.Blanco, S., Peralta, S., Morales, M. E., Martínez-Lara, E., Pedrajas, J. R., Castán, H., Peinado, M. Á., & Ruiz, M. A. (2020).Pharmaceutics12(1), 40.

https://doi.org/10.3390/pharmaceutics12010040

Effects of Olive Oil Consumption on Cardiovascular Risk Factors in Patients with Fibromyalgia.Rus, A., Molina, F., Martínez-Ramírez, M. J., Aguilar-Ferrándiz, M. E., Carmona, R., & Del Moral, M. L. (2020).Nutrients12(4), 918.

https://doi.org/10.3390/nu12040918

Antiproliferative and Pro-Apoptotic Effect of Uvaol in Human Hepatocarcinoma HepG2 Cells by Affecting G0/G1 Cell Cycle Arrest, ROS Production and AKT/PI3K Signaling Pathway. Bonel-Pérez, G. C., Pérez-Jiménez, A., Gris-Cárdenas, I., Parra-Pérez, A. M., Lupiáñez, J. A., Reyes-Zurita, F. J., Siles, E., Csuk, R., Peragón, J., & Rufino-Palomares, E. E. (2020). Molecules (Basel, Switzerland)25(18), 4254

https://doi.org/10.3390/molecules25184254

Hydroxytyrosol as a Promising Ally in the Treatment of Fibromyalgia.Ramírez-Tejero, J. A., Martínez-Lara, E., Peinado, M. Á., Del Moral, M. L., & Siles, E. (2020). Nutrients12(8), 2386.

https://doi.org/10.3390/nu12082386

Crosstalk between hydroxytyrosol, a major olive oil phenol, and HIF-1 in MCF-7 breast cancer cells. Calahorra, J., Martínez-Lara, E., Granadino-Roldán, J. M., Martí, J. M., Cañuelo, A., Blanco, S., Oliver, F. J., & Siles, E. (2020). Scientific reports10(1), 6361.

https://doi.org/10.1038/s41598-020-63417-6

Validation of the Spanish version of the migraine disability assessment questionnaire (MIDAS) in university students with migraine. Rodríguez-Almagro, D., Achalandabaso, A., Rus, A., Obrero-Gaitán, E., Zagalaz-Anula, N., & Lomas-Vega, R. (2020). BMC neurology20(1), 67.

https://doi.org/10.1186/s12883-020-01646-y

MCPH1 Lack of Function Enhances Mitotic Cell Sensitivity Caused by Catalytic Inhibitors of Topo II.Arroyo, M., Sánchez, A., Cañuelo, A., Heredia-Molina, R. F., Martínez-Molina, E., Clarke, D. J., & Marchal, J. A. (2020).Genes11(4), 406.

https://doi.org/10.3390/genes11040406

Mitotic entry upon Topo II catalytic inhibition is controlled by Chk1 and Plk1.Arroyo, M., Cañuelo, A., Calahorra, J., Hastert, F. D., Sánchez, A., Clarke, D. J., & Marchal, J. A. (2020). The FEBS journal287(22), 4933–4951.

 https://doi.org/10.1111/febs.15280

Synthesis and characterization of different sodium hyaluronate nanoparticles to transport large neurotherapheutic molecules through blood brain barrier after stroke. Sebastián Peralta, Santos Blanco, Raquel Hernández, Herminia Castán, Eva Siles, Esther Martínez-Lara, María Encarnación Morales, María Ángeles Peinado, María Adolfina Ruiz. (2019). European Polymer Journal, 112, 433-441.

https://doi.org/10.1016/j.eurpolymj.2019.01.030.

Lateral habenula lesions disrupt appetitive extinction, but do not affect voluntary alcohol consumption.Donaire, R., Morón, I., Blanco, S., Villatoro, A., Gámiz, F., Papini, M. R., & Torres, C. (2019).Neuroscience letters703, 184–190.

https://doi.org/10.1016/j.neulet.2019.03.044

Are Patients With Fibromyalgia in a Prothrombotic State?. Molina, F., Del Moral, M. L., La Rubia, M., Blanco, S., Carmona, R., & Rus, A. (2019).Biological research for nursing21(2), 224–230.

https://doi.org/10.1177/1099800418824716

Mediterranean Diet, Body Composition, and Activity Associated With Bone Health in Women With Fibromyalgia Syndrome. Correa-Rodríguez, M., El Mansouri-Yachou, J., Tapia-Haro, R. M., Molina, F., Rus, A., Rueda-Medina, B., & Aguilar-Ferrandiz, M. E. (2019). Nursing research68(5), 358–364.

https://doi.org/10.1097/NNR.0000000000000361

Misperception of the subjective visual vertical in neurological patients with or without stroke: A meta-analysis.Molina, F., Lomas-Vega, R., Obrero-Gaitán, E., Rus, A., Almagro, D. R., & Del-Pino-Casado, R. (2019). NeuroRehabilitation44(3), 379–388.

https://doi.org/10.3233/NRE-182642

Altered Serum Oxytocinase and Enkephalin-Degrading Aminopeptidase Activities in Patients With Fibromyalgia. Martínez-Martos, J. M., Correa-Rodríguez, M., Rus, A., Molina, F., Ramírez-Expósito, M. J., & Aguilar-Ferrandiz, M. E. (2019). Biological research for nursing21(4), 431–439.

https://doi.org/10.1177/1099800419854207

Hydroxytyrosol, the Major Phenolic Compound of Olive Oil, as an Acute Therapeutic Strategy after Ischemic Stroke. Calahorra, J., Shenk, J., Wielenga, V. H., Verweij, V., Geenen, B., Dederen, P. J., Peinado, M. Á., Siles, E., Wiesmann, M., & Kiliaan, A. J. (2019). Nutrients11(10), 2430.

https://doi.org/10.3390/nu11102430

Tyrosol, a simple phenol from EVOO, targets multiple pathogenic mechanisms of neurodegeneration in a C. elegans model of Parkinson’s disease. Garcia-Moreno, J. C., Porta de la Riva, M., Martínez-Lara, E., Siles, E., & Cañuelo, A. (2019). Neurobiology of aging82, 60–68.

https://doi.org/10.1016/j.neurobiolaging.2019.07.003

MCPH1 is essential for cellular adaptation to the G2-phase decatenation checkpoint. Arroyo, M., Kuriyama, R., Guerrero, I., Keifenheim, D., Cañuelo, A., Calahorra, J., Sánchez, A., Clarke, D. J., & Marchal, J. A. (2019). FASEB journal : official publication of the Federation of American Societies for Experimental Biology33(7), 8363–8374.

https://doi.org/10.1096/fj.201802009RR

Catecholamine and Indolamine Pathway: A Case-Control Study in Fibromyalgia.Rus, A., Molina, F., Del Moral, M. L., Ramírez-Expósito, M. J., & Martínez-Martos, J. M. (2018).Biological research for nursing20(5), 577–586.

 https://doi.org/10.1177/1099800418787672

Insight into the biological pathways underlying fibromyalgia by a proteomic approach.Ramírez-Tejero, J. A., Martínez-Lara, E., Rus, A., Camacho, M. V., Del Moral, M. L., & Siles, E. (2018). Journal of proteomics186, 47–55.

 https://doi.org/10.1016/j.jprot.2018.07.009

Hypoxia modulates the antioxidant effect of hydroxytyrosol in MCF-7 breast cancer cells.Calahorra, J., Martínez-Lara, E., De Dios, C., & Siles, E. (2018). PloS one13(9), e0203892.

 https://doi.org/10.1371/journal.pone.0203892

Extra Virgin Olive Oil Improves Oxidative Stress, Functional Capacity, and Health-Related Psychological Status in Patients With Fibromyalgia: A Preliminary Study.Rus, A., Molina, F., Ramos, M. M., Martínez-Ramírez, M. J., & Del Moral, M. L. (2017). Biological research for nursing19(1), 106–115.

https://doi.org/10.1177/1099800416659370

Angiogenesis is VEGF-independent in the aged striatum of male rats exposed to acute hypoxia. Molina, F., Del Moral, M. L., Peinado, M. Á., & Rus, A. (2017).Biogerontology18(5), 759–768.

https://doi.org/10.1007/s10522-017-9709-5 

Response of the Nitric Oxide System to Hypobaric Hypoxia in the Aged Striatum. Molina, F., Del Moral, M. L., Peinado, M. Á., & Rus, A. (2017). Gerontology63(1), 36–44.

https://doi.org/10.1159/000450607

Melatonin influences NO/NOS pathway and reduces oxidative and nitrosative stress in a model of hypoxic-ischemic brain damage. Blanco, S., Hernández, R., Franchelli, G., Ramos-Álvarez, M. M., & Peinado, M. Á. (2017).Nitric oxide : biology and chemistry62, 32–43.

https://doi.org/10.1016/j.niox.2016.12.001

Comparative proteomic study of early hypoxic response in the cerebral cortex of rats submitted to two different hypoxic models.Ovelleiro, D., Blanco, S., Hernández, R., & Peinado, M. Á. (2017).Proteomics. Clinical applications11(11-12), 10.1002/prca.201700058.

https://doi.org/10.1002/prca.201700058

MCPH1, mutated in primary microcephaly, is required for efficient chromosome alignment during mitosis. Arroyo, M., Kuriyama, R., Trimborn, M., Keifenheim, D., Cañuelo, A., Sánchez, A., Clarke, DJ, & Marchal, JA (2017). Scientific reports7 (1), 13019.

 https://doi.org/10.1038/s41598-017-12793-7

Effectiveness of Global Postural Re-education for Treatment of Spinal Disorders: A Meta-analysis. Lomas-Vega, R., Garrido-Jaut, MV, Rus, A., y Del-Pino-Casado, R. (2017).  American journal of physical medicine & rehabilitation96 (2), 124–130.

 https://doi.org/10.1097/PHM.0000000000000575

Experienced versus Inexperienced Interexaminer Reliability on Location and Classification of Myofascial Trigger Point Palpation to Diagnose Lateral Epicondylalgia: An Observational Cross-Sectional Study.  Mora-Relucio, R., Núñez-Nagy, S., Gallego-Izquierdo, T., Rus, A., Plaza-Manzano, G., Romero-Franco, N., Ferragut-Garcías, A., y Pecos-Martín, D. (2016). Evidence-based complementary and alternative medicine : eCAM2016, 6059719. https://doi.org/10.1155/2016/6059719

Hydroxytyrosol decreases the oxidative and nitrosative stress levels and promotes angiogenesis through HIF-1 independent mechanisms in renal hypoxic cells. Martínez-Lara, E., Peña, A., Calahorra, J., Cañuelo, A., & Siles, E. (2016).  Food & function7 (1), 540–548.

https://doi.org/10.1039/c5fo00928f

Temporal profiles of blood pressure, circulating nitric oxide, and adrenomedullin as predictors of clinical outcome in acute ischemic stroke patients. Serrano-Ponz, M., Rodrigo-Gasqué, C., Siles, E., Martínez-Lara, E., Ochoa-Callejero, L., y Martínez, A. (2016). Molecular medicine reports13 (5), 3724–3734.

https://doi.org/10.3892/mmr.2016.5001

Gene expression profiling to investigate tyrosol-induced lifespan extension in Caenorhabditis elegans. Cañuelo, A., Esteban, FJ, y Peragón, J. (2016).  European journal of nutrition, 55 (2), 639–650.

https://doi.org/10.1007/s00394-015-0884-3

Nitric Oxide, Inflammation, Lipid Profile, and Cortisol in Normal- and Overweight Women With Fibromyalgia. Rus, A., Molina, F., Gassó, M., Camacho, MV, Peinado, M. Á., y del Moral, ML (2016). Biological research for nursing18(2), 138–146.

https://doi.org/10.1177/1099800415591035

Effects of a human milk oligosaccharide, 2′-fucosyllactose, on hippocampal long-term potentiation and learning capabilities in rodents. Vázquez, E., Barranco, A., Ramírez, M., Gruart, A., Delgado-García, J. M., Martínez-Lara, E., Blanco, S., Martín, M. J., Castanys, E., Buck, R., Prieto, P., & Rueda, R. (2015). The Journal of nutritional biochemistry26(5), 455–465.

https://doi.org/10.1016/j.jnutbio.2014.11.016

Study of tamoxifen urinary metabolites in rat by ultra-high-performance liquid chromatography time-of-flight mass spectrometry. Domínguez-Romero, JC, García-Reyes, JF, Beneito-Cambra, M., Martínez-Romero, R., Martinez-Lara, E., Del Moral-Leal, ML, y Molina-Díaz, A. (2015). Biomedical chromatography : BMC29 (8), 1220–1228.

https://doi.org/10.1002/bmc.3411

Shorter telomere length predicts poorer immunological recovery in virologically suppressed HIV-1-infected patients treated with combined antiretroviral therapy. Blanco, JR, Jarrin, I., Martinez, A., Siles, E., Larrayoz, IM, Cañuelo, A., Gutierrez, F., Gonzalez-Garcia, J., Vidal, F., Moreno, S., & CoRIS-Biobanco (2015).Journal of acquired immune deficiency syndromes (1999)68(1), 21–29.

https://doi.org/10.1097/QAI.0000000000000398

Proteomic characterization of nitrated cell targets after hypobaric hypoxia and reoxygenation in rat brain. Peinado, M. Á., Hernández, R., Peragón, J., Ovelleiro, D., Pedrosa, J. Á., & Blanco, S. (2014). Journal of proteomics109, 309–321.

https://doi.org/10.1016/j.jprot.2014.07.015

Oral quercetin supplementation hampers skeletal muscle adaptations in response to exercise training.Casuso, R. A., Martínez-López, E. J., Nordsborg, N. B., Hita-Contreras, F., Martínez-Romero, R., Cañuelo, A., & Martínez-Amat, A. (2014). Scandinavian journal of medicine & science in sports24(6), 920–927.

https://doi.org/10.1111/sms.12136

Dexamethasone upregulates Nox1 expression in vascular smooth muscle cells.Siuda, D., Tobias, S., Rus, A., Xia, N., Förstermann, U., & Li, H. (2014).  Pharmacology94(1-2), 13–20.

https://doi.org/10.1159/000365932

Interaction between PARP-1 and HIF-2α in the hypoxic response. Gonzalez-Flores, A., Aguilar-Quesada, R., Siles, E., Pozo, S., Rodríguez-Lara, M. I., López-Jiménez, L., López-Rodríguez, M., Peralta-Leal, A., Villar, D., Martín-Oliva, D., del Peso, L., Berra, E., & Oliver, F. J. (2014). Oncogene33(7), 891–898.

https://doi.org/10.1038/onc.2013.9

The combination of oral quercetin supplementation and exercise prevents brain mitochondrial biogenesis.Casuso, R. A., Martínez-López, E. J., Hita-Contreras, F., Camiletti-Moiron, D., Martínez-Romero, R., Cañuelo, A., & Martínez-Amat, A. (2014). Genes & nutrition9(5), 420.

https://doi.org/10.1007/s12263-014-0420-8

Hypobaric hypoxia and reoxygenation induce proteomic profile changes in the rat brain cortex. Hernández, R., Blanco, S., Peragón, J., Pedrosa, J. Á., & Peinado, M. Á. (2013). Neuromolecular medicine15(1), 82–94.

https://doi.org/10.1007/s12017-012-8197-7

Proteomics analysis in Caenorhabditis elegans to elucidate the response induced by tyrosol, an olive phenol that stimulates longevity and stress resistance. Cañuelo, A., & Peragón, J. (2013). Proteomics13(20), 3064–3075.

https://doi.org/10.1002/pmic.201200579

Is fibromyalgia-related oxidative stress implicated in the decline of physical and mental health status?.La Rubia, M., Rus, A., Molina, F., & Del Moral, M. L. (2013). Clinical and experimental rheumatology31(6 Suppl 79), S121–S127.

Combined data mining strategy for the systematic identification of sport drug metabolites in urine by liquid chromatography time-of-flight mass spectrometry. Domínguez-Romero, J. C., García-Reyes, J. F., Martínez-Romero, R., Berton, P., Martínez-Lara, E., Del Moral-Leal, M. L., & Molina-Díaz, A. (2013). Analytica chimica acta761, 1–10.

https://doi.org/10.1016/j.aca.2012.11.049

Detection of main urinary metabolites of β2-agonists clenbuterol, salbutamol and terbutaline by liquid chromatography high resolution mass spectrometry. Domínguez-Romero, J. C., García-Reyes, J. F., Martínez-Romero, R., Martínez-Lara, E., Del Moral-Leal, M. L., & Molina-Díaz, A. (2013). Journal of chromatography. B, Analytical technologies in the biomedical and life sciences923-924, 128–135.

https://doi.org/10.1016/j.jchromb.2013.02.008

Short-term hypoxia/reoxygenation activates the angiogenic pathway in rat caudate putamen.Molina, F., Rus, A., Peinado, M. A., & Del Moral, M. L. (2013). Journal of biosciences38(2), 363–371.

https://doi.org/10.1007/s12038-013-9327-6

Acute hypoxia-induced depletion of striatal nitric oxide synthase pathway.Molina, F., Rus, A., Pedrosa, J. Á., & del Moral, M. L. (2013).Journal of chemical neuroanatomy47, 42–49.

https://doi.org/10.1016/j.jchemneu.2012.12.003 

Effects of co-administration of the nitric oxide donor ISMN and melatonin in the NO system in a model of hypobaric hypoxia. Raquel Hernandez, Santos Blanco, Juan Angel Pedrosa, Maria Angeles Peinado. (2012). Nitric Oxide, 27, 18.

https://doi.org/10.1016/j.niox.2012.04.063.

NO/NOS system is diminished after acute hypobaric hypoxia in rat striatum.Francisco Molina, Alma Rus, Maria Luisa del Moral, Ma Ángeles Peinado. (2012). Nitric Oxide, 27, 18-19,

https://doi.org/10.1016/j.niox.2012.04.066

Role of melatonin and the nitric oxide donor ISMN in a model of brain ischemic-hypobaric hypoxia. Maria Angeles Peinado, Raquel Hernandez, Juan Angel Pedrosa, Santos Blanco. (2012). Nitric Oxide, 27, 18,

https://doi.org/10.1016/j.niox.2012.04.064

The hypoxic preconditioning agent deferoxamine induces poly(ADP-ribose) polymerase-1-dependent inhibition of the mitochondrial respiratory chain.Cañuelo, A., Martínez-Romero, R., Martínez-Lara, E., Sánchez-Alcázar, J. A., & Siles, E. (2012). Molecular and cellular biochemistry363(1-2), 101–108.

https://doi.org/10.1007/s11010-011-1162-1

ROS-induced DNA damage and PARP-1 are required for optimal induction of starvation-induced autophagy.Rodríguez-Vargas, J. M., Ruiz-Magaña, M. J., Ruiz-Ruiz, C., Majuelos-Melguizo, J., Peralta-Leal, A., Rodríguez, M. I., Muñoz-Gámez, J. A., de Almodóvar, M. R., Siles, E., Rivas, A. L., Jäättela, M., & Oliver, F. J. (2012).Cell research22(7), 1181–1198.

https://doi.org/10.1038/cr.2012.70

Tyrosol, a main phenol present in extra virgin olive oil, increases lifespan and stress resistance in Caenorhabditis elegans.Cañuelo, A., Gilbert-López, B., Pacheco-Liñán, P., Martínez-Lara, E., Siles, E., & Miranda-Vizuete, A. (2012). Mechanisms of ageing and development133(8), 563–574.

https://doi.org/10.1016/j.mad.2012.07.004

Nitric oxide modulates hypoxia-inducible factor-1 and poly(ADP-ribose) polymerase-1 cross talk in response to hypobaric hypoxia. Martínez-Romero, R., Cañuelo, A., Siles, E., Oliver, F. J., & Martínez-Lara, E. (2012). Journal of applied physiology (Bethesda, Md.: 1985)112(5), 816–823.

https://doi.org/10.1152/japplphysiol.00898.2011

Physiologic Rationale for Selection of Tendinopathy Treatments.Molina, F., Rus, A., Lomas-Vega, R., & Moral, M. L. d. (2012).International Journal of Athletic Therapy and Training, 17(3), 37-40

https://doi.org/10.1123/ijatt.17.3.37

The Physiologic Basis of Tendinopathy Development.Molina, F., Rus, A., Lomas-Vega, R., & del Moral, M. L. (2011).  International Journal of Athletic Therapy and Training, 16(6), 5-8. Retrieved Apr 11, 2024, from

https://doi.org/10.1123/ijatt.16.6.5

Is endothelial-nitric-oxide-synthase-derived nitric oxide involved in cardiac hypoxia/reoxygenation-related damage?. Rus, A., Peinado, M. A., Blanco, S., & Del Moral, M. L. (2011). Journal of biosciences36(1), 69–78.

https://doi.org/10.1007/s12038-011-9006-4

Upregulation of cardiac NO/NOS system during short-term hypoxia and the subsequent reoxygenation period.Rus, A., Del Moral, M. L., Molina, F., & Peinado, M. A. (2011). European journal of histochemistry : EJH55(2), e17.

https://doi.org/10.4081/ejh.2011.e17

Does inducible NOS have a protective role against hypoxia/reoxygenation injury in rat heart?. Rus, A., del Moral, M. L., Molina, F., & Peinado, M. A. (2011).Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology20(1), e17–e25.

https://doi.org/10.1016/j.carpath.2010.01.002

Nitric oxide averts hypoxia-induced damage during reoxygenation in rat heart.Rus, A., Molina, F., Peinado, M. Á., & Del Moral, M. L. (2011).Microscopy research and technique74(12), 1093–1103.

https://doi.org/10.1002/jemt.21000

Endothelial NOS-derived nitric oxide prevents injury resulting from reoxygenation in the hypoxic lung.Rus, A., Molina, F., Peinado, M. A., & del Moral, M. L. (2010). Free radical research44(9), 1027–1035.

https://doi.org/10.3109/10715762.2010.498479

Endogenous nitric oxide can act as beneficial or deleterious in the hypoxic lung depending on the reoxygenation time.Rus, A., Molina, F., Peinado, M. Á., & Del Moral, M. L. (2010). Anatomical record (Hoboken, N.J. : 2007)293(12), 2193–2201.

https://doi.org/10.1002/ar.21229

Inducible NOS inhibitor 1400W reduces hypoxia/re-oxygenation injury in rat lung.Rus, A., Castro, L., Del Moral, M. L., & Peinado, A. (2010). Redox report : communications in free radical research15(4), 169–178.

https://doi.org/10.1179/174329210X12650506623609

Study of the nitric oxide system in the rat cerebellum during aging. Blanco, S., Molina, F. J., Castro, L., Del Moral, M. L., Hernandez, R., Jimenez, A., Rus, A., Martinez-Lara, E., Siles, E., & Peinado, M. A. (2010). BMC neuroscience11, 78.

https://doi.org/10.1186/1471-2202-11-78

Lung eNOS and iNOS are reoxygenation time-dependent upregulated after acute hypoxia.Rus, A., Peinado, M. A., Castro, L., & Del Moral, M. L. (2010). Anatomical record (Hoboken, N.J. : 2007)293(6), 1089–1098.

https://doi.org/10.1002/ar.21141

Olive oil and health: summary of the II international conference on olive oil and health consensus report, Jaén and Córdoba (Spain) 2008.López-Miranda, J., Pérez-Jiménez, F., Ros, E., De Caterina, R., Badimón, L., Covas, M. I., Escrich, E., Ordovás, J. M., Soriguer, F., Abiá, R., de la Lastra, C. A., Battino, M., Corella, D., Chamorro-Quirós, J., Delgado-Lista, J., Giugliano, D., Esposito, K., Estruch, R., Fernandez-Real, J. M., Gaforio, J. J., … Yiannakouris, N. (2010).Nutrition, metabolism, and cardiovascular diseases : NMCD20(4), 284–294.

https://doi.org/10.1016/j.numecd.2009.12.007 

Phenylalanine ammonia-lyase, polyphenol oxidase, and phenol concentration in fruits of Olea europaea L. cv. Picual, Verdial, Arbequina, and Frantoio during ripening.Ortega-García, F., & Peragón, J. (2009).Journal of agricultural and food chemistry57(21), 10331–10340.

https://doi.org/10.1021/jf901471c

Poly(ADP-ribose) polymerase-1 modulation of in vivo response of brain hypoxia-inducible factor-1 to hypoxia/reoxygenation is mediated by nitric oxide and factor inhibiting HIF.Martínez-Romero, R., Cañuelo, A., Martínez-Lara, E., Javier Oliver, F., Cárdenas, S., & Siles, E. (2009). Journal of neurochemistry111(1), 150–159.

https://doi.org/10.1111/j.1471-4159.2009.06307.x

Polyphenol oxidase and its relationship with oleuropein concentration in fruits and leaves of olive (Olea europaea) cv. ‘Picual’ trees during fruit ripening. Ortega-García, F., Blanco, S., Peinado, M. A., & Peragón, J. (2008). Tree physiology28(1), 45–54.

https://doi.org/10.1093/treephys/28.1.45

PARP-1 modulates deferoxamine-induced HIF-1alpha accumulation through the regulation of nitric oxide and oxidative stress.Martínez-Romero, R., Martínez-Lara, E., Aguilar-Quesada, R., Peralta, A., Oliver, F. J., & Siles, E. (2008). Journal of cellular biochemistry104(6), 2248–2260.

https://doi.org/10.1002/jcb.21781

Age modulates the nitric oxide system response in the ischemic cerebellum.Blanco, S., Castro, L., Hernández, R., Del Moral, M. L., Pedrosa, J. A., Martínez-Lara, E., Siles, E., & Peinado, M. A. (2007). Brain research1157, 66–73.

https://doi.org/10.1016/j.brainres.2007.01.141

Age and sex-related serum changes in nitric oxide: correlations with serological markers.Peinado, M. A., López-Ramos, J. C., Camacho, M. V., Molina, F. J., Martínez-Romero, R., Hernández, R., Siles, E., Martínez-Lara, E., Del Moral, M. L., Pedrosa, J. A., & Gásso, M. (2007).International journal of cardiology121(1), 88–90.

https://doi.org/10.1016/j.ijcard.2006.08.032

The nitric oxide system response to hypoxia/reoxygenation in the aged cerebral cortex.Cañuelo, A., Siles, E., Martínez-Romero, R., Peinado, M. A., & Martínez-Lara, E. (2007). Experimental gerontology42(12), 1137–1145.

https://doi.org/10.1016/j.exger.2007.09.006

Aging affects but does not eliminate the enzymatic antioxidative response to hypoxia/reoxygenation in cerebral cortex. Martínez-Romero, R., Cañuelo, A., Martínez-Lara, E., Hernández, R., Del Moral, M. L., Pedrosa, J. A., Peinado, M. A., & Siles, E. (2006). Experimental gerontology41(1), 25–31.

https://doi.org/10.1016/j.exger.2005.09.009

Downregulation in the expression of the serine dehydratase in the rat liver during chronic metabolic acidosis.López-Flores, I., Peragón, J., Valderrama, R., Esteban, F. J., Luque, F., Peinado, M. A.,Aranda, F., Lupiáñez, J. A., & Barroso, J. B. (2006). American journal of physiology. Regulatory, integrative and comparative physiology291(5), R1295–R1302.

https://doi.org/10.1152/ajpregu.00095.2006

Steatosis recovery after treatment with a balanced sunflower or olive oil-based diet: involvement of perisinusoidal stellate cells. Hernández, R., Martínez-Lara, E., Cañuelo, A., del Moral, M. L., Blanco, S., Siles, E., Jiménez, A., Pedrosa, J. A., & Peinado, M. A. (2005). World journal of gastroenterology11(47), 7480–7485.

https://doi.org/10.3748/wjg.v11.i47.7480 

Colorimetric quantification and in situ detection of collagen.Francisco J. Esteban, María L. del Moral, Ana M. Sánchez-López, Santos Blanco, Ana Jiménez, Raquel Hernández, Juan A. Pedrosa & María A. Peinado. (2005).  Journal of Biological Education, 39(4), 183-186,

https://doi.org/10.1080/00219266.2005.9655994

Constitutive nitric oxide synthases are responsible for the nitric oxide production in the ischemic aged cerebral cortex. Martínez-Lara, E., Cañuelo, A. R., Siles, E., Hernández, R., Del Moral, M. L., Blanco, S., Pedrosa, J. A., Rodrigo, J., & Peinado, M. A. (2005).  Brain research1054(1), 88–94.

https://doi.org/10.1016/j.brainres.2005.06.060

PARP-1-dependent 3-nitrotyrosine protein modification after DNA damage.Siles, E., Martinez-Lara, E., Núñez, M. I., Muñoz-Gámez, J. A., Martín-Oliva, D., Valenzuela, M. T., Peinado, M. A., Ruiz de Almodóvar, J. M., & Javier Oliver, F. (2005). Journal of cellular biochemistry96(4), 709–715.

https://doi.org/10.1002/jcb.20570

Evidence of a decrease in nitric oxide-storage molecules following acute hypoxia and/or hypobaria, by means of chemiluminescence analysis.López-Ramos, J. C., Martínez-Romero, R., Molina, F., Cañuelo, A., Martínez-Lara, E., Siles, E., & Peinado, M. A. (2005).Nitric oxide : biology and chemistry13(1), 62–67.

https://doi.org/10.1016/j.niox.2005.05.003

Serine dehydratase expression decreases in rat livers injured by chronic thioacetamide ingestion. López-Flores, I., Barroso, J. B., Valderrama, R., Esteban, F. J., Martínez-Lara, E., Luque, F., Peinado, M. A., Ogawa, H., Lupiáñez, J. A., & Peragón, J. (2005). Molecular and cellular biochemistry268(1-2), 33–43.

https://doi.org/10.1007/s11010-005-2995-2

Immunohistochemistry of neuronal nitric oxide synthase and protein nitration in the striatum of the aged rat.Del Moral, M. L., Esteban, F. J., Hernández, R., Blanco, S., Molina, F. J., Martínez-Lara, E., Siles, E., Viedma, G., Ruiz, A., Pedrosa, J. A., & Peinado, M. A. (2004).Microscopy research and technique64(4), 304–311.

https://doi.org/10.1002/jemt.20081

Upregulation of endothelial nitric oxide synthase maintains nitric oxide production in the cerebellum of thioacetamide cirrhotic rats.Hernández, R., Martínez-Lara, E., Del Moral, M. L., Blanco, S., Cañuelo, A., Siles, E., Esteban, F. J., Pedrosa, J. A., & Peinado, M. A. (2004). Neuroscience126(4), 879–887.

https://doi.org/10.1016/j.neuroscience.2004.04.010

Glutathione S-transferase isoenzymatic response to aging in rat cerebral cortex and cerebellum. Martínez-Lara, E., Siles, E., Hernández, R., Cañuelo, A. R., Luisa del Moral, M., Jiménez, A., Blanco, S., López-Ramos, J. C., Esteban, F. J., Pedrosa, J. A., & Peinado, M. A. (2003). Neurobiology of aging24(3), 501–509.

https://doi.org/10.1016/s0197-4580(02)00139-2

Reactive oxygen species mediate the down-regulation of mitochondrial transcripts and proteins by tumour necrosis factor-alpha in L929 cells. Sánchez-Alcázar, J. A., Schneider, E., Hernández-Muñoz, I., Ruiz-Cabello, J., Siles-Rivas, E., de la Torre, P., Bornstein, B., Brea, G., Arenas, J., Garesse, R., Solís-Herruzo, J. A., Knox, A. J., & Navas, P. (2003). The Biochemical journal370(Pt 2), 609–619.

https://doi.org/10.1042/BJ20021623

Postnatal changes in the nitric oxide system of the rat cerebral cortex after hypoxia during delivery. Fernández, A. P., Alonso, D., Lisazoaín, I., Serrano, J., Leza, J. C., Bentura, M. L., López, J. C., Manuel Encinas, J., Fernández-Vizarra, P., Castro-Blanco, S., Martínez, A., Martinez-Murillo, R., Lorenzo, P., Pedrosa, J. A.,Peinado, M. A., & Rodrigo, J. (2003). Brain research. Developmental brain research142(2), 177–192.

https://doi.org/10.1016/s0165-3806(03)00068-3

Age-related changes of the nitric oxide system in the rat brain.Siles, E., Martínez-Lara, E., Cañuelo, A., Sánchez, M., Hernández, R., López-Ramos, J. C., Del Moral, M. L., Esteban, F. J., Blanco, S., Pedrosa, J. A., Rodrigo, J., & Peinado, M. A. (2002).  Brain research956(2), 385–392.

https://doi.org/10.1016/s0006-8993(02)03575-8

Evidence from heterologous expression of glutathione S-transferases A and A1 of the plaice (Pleuronectes platessa) that their endogenous role is in detoxification of lipid peroxidation products. Martinez-Lara, E., Leaver, M., & George, S. (2002). Marine environmental research54(3-5), 263–266.

https://doi.org/10.1016/s0141-1136(02)00188-5 

Histochemical and ultrastructural study of the chicken salivary palatine glands. Samar, M. E., Avila, R. E., Esteban, F. J., Olmedo, L., Dettin, L., Massone, A., Pedrosa, J. A., & Peinado, M. A. (2002). Acta histochemica104(2), 199–207.

https://doi.org/10.1078/0065-1281-00627

The nitrergic autonomic innervation of the liver.Peinado, M. A., del Moral, M. L., Jiménez, A., Rodrigo, J., & Esteban, F. J. (2002). Autonomic neuroscience : basic & clinical99(2), 67–69.

https://doi.org/10.1016/s1566-0702(02)00135-2

Immunohistochemical localisation of neuronal nitric oxide synthase in the rainbow trout kidney. Jiménez, A., Esteban, F. J., Sánchez-López, A. M., Pedrosa, J. A., Del Moral, M. L., Hernández, R., Blanco, S., Barroso, J. B., Rodrigo, J., & Peinado, M. A. (2001).  Journal of chemical neuroanatomy21(4), 289–294.

https://doi.org/10.1016/s0891-0618(01)00116-8

Neuronal nitric oxide synthase immunoreactivity in the guinea-pig liver: distribution and colocalization with neuropeptide Y and calcitonin gene-related peptide.Esteban, F. J., Jiménez, A., Fernández, A. P., del Moral, M. L., Sánchez-López, A. M., Hernández, R., Garrosa, M., Pedrosa, J. A., Rodrigo, J., & Peinado, M. A. (2001).  Liver21(6), 374–379.

https://doi.org/10.1034/j.1600-0676.2001.210602.x

Envejecimiento y neurodegeneración: bases moleculares y celulares [Aging and neurodegeneration: molecular and cellular bases].Peinado, M. A., del Moral, M. L., Esteban, F. J., Martínez-Lara, E., Siles, E., Jiménez, A., Hernández-Cobo, R., Blanco, S., Rodrigo, J., & Pedrosa, J. A. (2000). Revista de neurologia31(11), 1054–1065.

Tumor necrosis factor-alpha increases the steady-state reduction of cytochrome b of the mitochondrial respiratory chain in metabolically inhibited L929 cells. Sánchez-Alcázar, J. A., Schneider, E., Martínez, M. A., Carmona, P., Hernández-Muñoz, I., Siles, E., De La Torre, P., Ruiz-Cabello, J., García, I., & Solis-Herruzo, J. A. (2000). The Journal of biological chemistry275(18), 13353–13361.

https://doi.org/10.1074/jbc.275.18.13353

Molecular and kinetic characterization and cell type location of inducible nitric oxide synthase in fish.Barroso, J. B., Carreras, A., Esteban, F. J., Peinado, M. A., Martínez-Lara, E., Valderrama, R., Jiménez, A., Rodrigo, J., & Lupiáñez, J. A. (2000). American journal of physiology. Regulatory, integrative and comparative physiology279(2), R650–R656.

https://doi.org/10.1152/ajpregu.2000.279.2.R650

Immunolocalization of the HNK-1 epitope in the autonomic innervation to the liver and upper digestive tract of the developing rat embryo. Peinad, M. A., Torres, M. I., Thompson, R. P., & Esteban, F. J. (2000). The Histochemical journal32(7), 439–446.

https://doi.org/10.1023/a:1004047422552

Levels of cellular glutathione and metallothionein affect the toxicity of oxidative stressors in an established carp cell line.Wright, J., George, S., Martinez-Lara, E., Carpene, E., & Kindt, M. (2000). Marine environmental research50(1-5), 503–508.

https://doi.org/10.1016/s0141-1136(00)00125-2

Effect of thioacetamide and dexamethasone on serum lipids in rats fed on high-fat sunflower or olive oil diets. Esteban, F. J., Sánchez-López, A. M., Del Moral, M. L., Camacho, M. V., Hernández, R., Jiménez, A., Pedrosa, J. A., & Peinado, M. A. (1999). Journal of nutritional science and vitaminology45(2), 231–238.

https://doi.org/10.3177/jnsv.45.231

Histochemical study of magellanic penguin (Spheniscus magellanicus) minor salivary glands during postnatal growth. Samar, M. E., Avila, R. E., De Fabro, S. P., Porfirio, V., Esteban, F. J., Pedrosa, J. A., & Peinado, M. A. (1999). The Anatomical record254(2), 298–306.

https://doi.org/10.1002/(SICI)1097-0185(19990201)254:2<298::AID-AR16>3.0.CO;2-7

DNA damage and prediction of radiation response in lymphocytes and epidermal skin human cells. Núñez, M. I., Guerrero, M. R., López, E., del Moral, M. R., Valenzuela, M. T., Siles, E., Villalobos, M., Pedraza, V., Peacock, J. H., & Ruiz de Almodóvar, J. M. (1998). International journal of cancer76(3), 354–361.

https://doi.org/10.1002/(sici)1097-0215(19980504)76:3<354::aid-ijc12>3.0.co;2-b

Distribution of nitric oxide synthase in the esophagus of the cat and monkey. Rodrigo, J., Uttenthal, L. O., Peinado, M. A., Esteban, F. J., Fernández, A. P., Serrano, J., Martínez de Velasco, J., Santacana, M., Bentura, M. L., Martínez-Murillo, R., & Pedrosa, J. A. (1998). Journal of the autonomic nervous system70(3), 164–179.

https://doi.or/10.1016/s0165-1838(98)00053-8

Impact of starvation-refeeding on kinetics and protein expression of trout liver NADPH-production systems. Barroso, J. B., Peragon, J., Contreras-Jurado, C., Garcia-Salguero, L., Corpas, F. J., Esteban, F. J., Peinado, M. A., De La Higuera, M., & Lupianez, J. A. (1998). The American journal of physiology274(6), R1578–R1587.

https://doi.org/10.1152/ajpregu.1998.274.6.R1578

Neuronal and inducible nitric oxide synthase and nitrotyrosine immunoreactivities in the cerebral cortex of the aging rat.Uttenthal, L. O., Alonso, D., Fernández, A. P., Campbell, R. O., Moro, M. A., Leza, J. C., Lizasoain, I., Esteban, F. J., Barroso, J. B., Valderrama, R., Pedrosa, J. A., Peinado, M. A., Serrano, J., Richart, A., Bentura, M. L., Santacana, M., Martínez-Murillo, R., & Rodrigo, J. (1998). Microscopy research and technique43(1), 75–88.

https://doi.org/10.1002/(SICI)1097-0029(19981001)43:1<75::AID-JEMT11>3.0.CO;2-0

Nitrergic innervation of the cat liver. Esteban, F. J., Pedrosa, J. A., Jiménez, A., del Moral, M. L., Rodrigo, J., & Peinado, M. A. (1998).Neuroscience letters243(1-3), 45–48.

https://doi.org/10.1016/s0304-3940(98)00083-4

Quantitative and ultrastructural changes in glia and pericytes in the parietal cortex of the aging rat. Peinado, M. A., Quesada, A., Pedrosa, J. A., Torres, M. I., Martinez, M., Esteban, F. J., Del Moral, M. L., Hernandez, R., Rodrigo, J., & Peinado, J. M. (1998). Microscopy research and technique43(1), 34–42.

https://doi.org/10.1002/(SICI)1097-0029(19981001)43:1<34::AID-JEMT6>3.0.CO;2-G

The innervation of rainbow trout (Oncorhynchus mykiss) liver: protein gene product 9.5 and neuronal nitric oxide synthase immunoreactivities. Esteban, F. J., Jiménez, A., Barroso, J. B., Pedrosa, J. A., del Moral, M. L., Rodrigo, J., & Peinado, M. A. (1998). Journal of anatomy193 ( Pt 2)(Pt 2), 241–249.

https://doi.org/10.1046/j.1469-7580.1998.19320241.x

Apoptosis after gamma irradiation. Is it an important cell death modality?. Siles, E., Villalobos, M., Jones, L., Guerrero, R., Eady, J. J., Valenzuela, M. T., Núñez, M. I., McMillan, T. J., & Ruiz de Almodóvar, J. M. (1998). British journal of cancer78(12), 1594–1599.

https://doi.org/10.1038/bjc.1998.728

Distribution of neuronal nitric oxide synthase in the rat liver. Esteban, F. J., Pedrosa, J. A., Jiménez, A., Fernández, A. P., Bentura, M. L., Martínez-Murillo, R., Rodrigo, J., & Peinado, M. A. (1997). Neuroscience letters226(2), 99–102.

https://doi.org/10.1016/s0304-3940(97)00262-0

High-fat sunflower and olive oil diets affect serum lipid levels in steatotic rat liver differently. Del Moral, M. L., Esteban, F. J., Torres, M. I., Camacho, M. V., Hernandez, R., Jimenez, A., Aránega, A., Pedrosa, J. A., & Peinado, M. A. (1997). Journal of nutritional science and vitaminology43(1), 155–160.

https://doi.org/10.3177/jnsv.43.155

Light microscopic quantification of morphological changes during aging in neurons and glia of the rat parietal cortex. Peinado, M. A., Quesada, A., Pedrosa, J. A., Martinez, M., Esteban, F. J., Del Moral, M. L., & Peinado, J. M. (1997). The Anatomical record247(3), 420–425.

https://doi.org/10.1002/(SICI)1097-0185(199703)247:3<420::AID-AR14>3.0.CO;2-R

A comparison of p53 and p16 expression in human tumor cells treated with hyperthermia or ionizing radiation. Valenzuela, M. T., Núñez, M. I., Villalobos, M., Siles, E., McMillan, T. J., Pedraza, V., & Ruiz de Almodóvar, J. M. (1997). International journal of cancer72(2), 307–312.

https://doi.org/10.1002/(sici)1097-0215(19970717)72:2<307::aid-ijc18>3.0.co;2-c

Tumor necrosis factor-alpha increases ATP content in metabolically inhibited L929 cells preceding cell death. Sánchez-Alcázar, J. A., Ruíz-Cabello, J., Hernández-Muñoz, I., Pobre, P. S., de la Torre, P., Siles-Rivas, E., García, I., Kaplan, O., Muñoz-Yagüe, M. T., & Solís-Herruzo, J. A. (1997). The Journal of biological chemistry272(48), 30167–30177.

https://doi.org/10.1074/jbc.272.48.30167

Antioxidant and detoxifying fish enzymes as biomarkers of river pollution. Lenártová, V., Holovská, K., Pedrajas, J. R., Martínez-Lara, E., Peinado, J., López-Barea, J., Rosival, I., & Košúth, P. (1997). Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals2(4), 247–252.

https://doi.org/10.1080/135475097231625

Purification and characterization of multiple glutathione transferase isoenzymes from grey mullet liver.Martínez-Lara, E., George, S. G., López-Barea, J., & Bárcena, J. A. (1997). Cellular and molecular life sciences : CMLS53(9), 759–768.

https://doi.org/10.1007/s000180050096

Glutathione-S-transferase isoenzyme patterns in the gilthead seabream (sparus aurata) exposed to environmental contaminants.E. Martínez-Lara, F. Toribio, J. López-Barea, J.A. Bárcena. (1996). Comparative Biochemistry and Physiology Part C: Pharmacology, Toxicology and Endocrinology, 113(2), 215-220.

https://doi.org/10.1016/0742-8413(95)02090-X.

Radiosensitivity of human breast cancer cell lines of different hormonal responsiveness. Modulatory effects of oestradiol. Villalobos, M., Becerra, D., Núñez, M. I., Valenzuela, M. T., Siles, E., Olea, N., Pedraza, V., & Ruiz de Almodóvar, J. M. (1996).International journal of radiation biology70(2), 161–169.

https://doi.org/10.1080/095530096145157

Relationship between p53 status and radiosensitivity in human tumour cell lines. Siles, E., Villalobos, M., Valenzuela, M. T., Núñez, M. I., Gordon, A., McMillan, T. J., Pedraza, V., & Ruiz de Almodóvar, J. M. (1996). British journal of cancer73(5), 581–588.

https://doi.org/10.1038/bjc.1996.101

Changes in GST-isoenzyme pattern of some organs of sheep exposed to different levels of pollution.Lenártová, V., Holovská, K., Martinez-Lara, E., López-Barea, J., Barcena, J. A., & Rosival, I. (1996). Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology114(2), 153–158.

https://doi.org/10.1016/0742-8413(96)00025-4

Methods for purification of glutathione peroxidase and related enzymes. Toribio, F., Martínez-Lara, E., Pascual, P., & López-Barea, J. (1996).Journal of chromatography. B, Biomedical applications684(1-2), 77–97.

https://doi.org/10.1016/0378-4347(95)00504-8

Relationship between doxorubicin cell sensitivity, drug-induced DNA double-strand breaks, glutathione content and P-glycoprotein in mammalian tumor cells.Valenzuela, M. T., Núñez, M. I., Villalobos, M., Siles, E., Olea, N., Pedraza, V., McMillan, T. J., & Ruíz de Almodóvar, J. M. (1995). Anti-cancer drugs6(6), 749–757.

https://doi.org/10.1097/00001813-199512000-00006

Biochemical and genetic indices of marine pollution in Spanish littoral. Rodríguez-Ariza, A., Martínez-Lara, E., Pascual, P., Pedrajas, J. R., Abril, N., Dorado, G., Toribio, F., Bárcena, J. A., Peinado, J., & Pueyo, C. (1993).  The Science of the total environmentSuppl Pt 1, 109–116.

https://doi.org/10.1016/s0048-9697(05)80009-9

Quantitative morphological changes in neurons and glia in the frontal lobe of the aging rat.Peinado, M. A., Martinez, M., Pedrosa, J. A., Quesada, A., & Peinado, J. M. (1993). The Anatomical record237(1), 104–108.

https://doi.org/10.1002/ar.1092370110

Direct assay of glutathione peroxidase activity using high-performance capillary electrophoresis. Pascual, P., Martinez-Lara, E., Bárcena, J. A., López-Barea, J., & Toribio, F. (1992). Journal of chromatography581(1), 49–56.

https://doi.org/10.1016/0378-4347(92)80446-w

Rapid method for the determination of glutathione transferase isoenzymes in crude extracts.  Martínez-Lara, E., Pascual, P., Toribio, F., López-Barea, J., & Bárcena, J. A. (1992). Journal of chromatography609(1-2), 141–146.

https://doi.org/10.1016/0021-9673(92)80157-p

HPLC isoenzyme patterns of glutathione transferase from marine fishes with different levels of pollution. Pascual, P., Martínez-Lara, E., Toribio, F., López-Barea, J., & Bárcena, J. A. (1991). Biochemical Society transactions19(3), 302S.

https://doi.org/10.1042/bst019302s

Morphological Modification in the Hepatocytes Induced by the Type of Fat in the Diet. Martinez M, Vilda P, Pedrosa JA, Del Moral ML, Rios A, Peinado MA. (1991). Histología Médica. 7 (1), 125 – 126.