¿Qué hacemos?

¿Qué hacemos?

Líneas de investigación

  • Estrés celular y edad

  • Hipoxia e isquemia. Bases celulares y moleculares

  • Estrés celular y fibromialgia

  • Estrés oxidativo y nitrosativo como base de enfermedades neurodegenerativas


Lipid nanoparticles for the transport of drugs like dopamine through the blood–brain barrier |2021| Ortega E, Blanco S, Ruiz A, Peinado MÁ, Peralta S, Morales ME. J Nanopart Res. 2021;23:106. https://doi.org/10.1007/s11051-021-05218-0

Impact of hydroxytyrosol on stroke: tracking therapy response on neuroinflammation and cerebrovascular parameters using PET-MR imaging and on functional outcomes |2021| Barca C, Wiesmann M, Calahorra J, Wachsmuth L, Döring C, Foray C, Heiradi A, Hermann S, Peinado MÁ, Siles E, Faber C, Schäfers M, Kiliaan AJ, Jacobs AH, Zinnhardt B. Theranostics. 2021; 11(9):4030-4049. https://doi.org/10.7150/thno.48110

Hyaluronate Nanoparticles as a Delivery System to Carry Neuroglobin to the Brain after Stroke |2020| Blanco S, Peralta S, Morales ME, Martínez-Lara E, Pedrajas JR, Castán H, Peinado MÁ, Ruiz MA. Pharmaceutics. 2020;12(1):E40. https://doi.org/10.3390/pharmaceutics12010040

Effects of olive oil consumption on cardiovascular risk factors in patients with Fibromyalgia |2020| Rus A, Molina F, Martínez-Ramírez MJ, Aguilar-Ferrándiz MA, Carmona R, del Moral ML. Nutrients. 2020;12(4):918. https://doi.org/10.3390/nu12040918

Effect of Uvaol in Human Hepatocarcinoma HepG2 Cells by Affecting G0/G1 Cell Cycle Arrest, ROS Production and AKT/PI3K Signaling Pathway |2020| Bonel-Pérez GC, Pérez-Jiménez A, Gris-Cárdenas I, Parra-Pérez AM, Lupiáñez JA, Reyes-Zurita FJ, Siles E, Csuk R, Peragón J, Rufino-Palomares EE. Molecules. 2020;25:E4254. https://doi.org/10.3390/molecules25184254

Hydroxytyrosol as a Promising Ally in the Treatment of Fibromyalgia |2020| Ramírez-Tejero JA, Martínez-Lara E, Peinado MÁ, del Moral ML, Siles E. Nutrients. 2020;12:2386. https://doi.org/10.3390/nu12082386

Crosstalk between hydroxytyrosol, a major olive oil phenol, and HIF-1 in MCF-7 breast cancer cells |2020| Calahorra J, Martínez-Lara E, Granadino-Roldán JM, Martí JM, Cañuelo A, Blanco S, Oliver FJ, Siles E. Sci Rep. 2020;10:6361. https://doi.org/10.1038/s41598-020-63417-6

Validation of the Spanish version of the migraine disability assessment questionnaire (MIDAS) in university students with migraine |2020|. Rodríguez-Almagro D, Achalandabaso A, Rus A, Obrero-Gaitán E, Zagalaz-Anula N, Lomas-Vega R. BMC Neurology. 2020;20:67-73. https://doi.org/10.1186/s12883-020-01646-y

MCPH1 lack of function enhances mitotic cell sensitivity caused by catalytic inhibitors of Topo II |2020| Arroyo M, Sánchez A, Cañuelo A, Heredia-Molina RF, Martínez-Molina E, Clarke DJ, Marchal JA. Genes. 2020;11(4):406. https://doi.org/10.3390/genes11040406

Mitotic entry upon Topo II catalytic inhibition is controlled by Chk1 and Plk1 |2020| Arroyo M, Cañuelo A, Calahorra J, Hastert FD, Sánchez A, Clarke DJ, Marchal JA. The FEBS Journal. 2020. https://doi.org/10.1111/febs.15280

Synthesis and characterization of different sodium hyaluronate nanoparticles to transport large neurotherapheutic molecules through blood brain barrier after stroke |2019| Peralta S, Blanco S, Hernández R, Castán H, Siles E, Martínez-Lara E, Morales ME, Peinado MÁ, Ruiz MA. Eur Polym J. 2019;112:433-441. https://doi.org/10.1016/j.eurpolymj.2019.01.030

Lateral habenula lesions disrupt appetitive extinction, but do not affect voluntary alcohol consumption |2019| Donaire R, Morón I, Blanco S, Villatoro Á, Gámiz F, Papini MR, Torres C. Neurosci Lett. 2019;703:184-190. https://doi.org/10.1016/j.neulet.2019.03.044

Are patients with fibromyalgia in a prothrombotic state? |2019| Molina F, del Moral ML, La Rubia M, Blanco S, Carmona R, Rus A. Biol Res Nurs. 2019;21(2):224-230. https://doi.org/10.1177/1099800418824716

Mediterranean Diet, Body Composition, and Activity Associated with Bone Health in Women with Fibromyalgia Syndrome |2019| Correa-Rodríguez M, El Mansouri-Yachou J, Tapia-Haro RM, Molina F, Rus A, Rueda-Medina B, Aguilar-Ferrándiz ME. Nurs Res. 2019;68(5):358-364. https://doi.org/10.1097/NNR.0000000000000361

Misperception of the subjective visual vertical in neurological patients with or without stroke: a meta-analysis |2019| Molina F, Lomas-Vega R, Obrero-Gaitán E, Rus A, Rodríguez-Almagro D, del-Pino-Casado R. NeuroRehabilitation. 2019;44(3):379-388. https://doi.org/10.3233/NRE-182642

Altered serum oxytocinase and enkephalin-degrading aminopeptidase specific activities in patients with fibromyalgia |2019| Martínez-Martos JM, Correa-Rodríguez M, Rus A, Molina F, Ramírez-Expósito MJ, Aguilar-Ferrándiz ME. Biol Res Nurs. 2019;21(4):431-439. https://doi.org/10.1177/1099800419854207

Hydroxytyrosol, the Major Phenolic Compound of Olive Oil, as an Acute Therapeutic Strategy after Ischemic Stroke /2019/ Calahorra J, Shenk J, Wielenga VH, Verweij V, Geenen B, Dederen PJ, Peinado MÁ, Siles E, Wiesmann M, Kiliaan AJ. Nutrients. 2019;11(10):2430. https://doi.org/10.3390/nu11102430

Tyrosol, a simple phenol from EVOO, targets multiple pathogenic mechanisms of neurodegeneration in a C. elegans model of Parkinson’s disease /2019/ García-Moreno JC, Porta de la Riva M, Martínez-Lara E, Siles E, Cañuelo A. Neurobiol Aging. 2019;82:60-68. https://doi.org/10.1016/j.neurobiolaging.2019.07.003

MCPH1 is essential for cellular adaptation to the G2-phase decatenation checkpoint |2019| Arroyo M, Kuriyama R, Guerrero I, Keifenheim D, Cañuelo A, Calahorra J, Sánchez A, Clarke DJ, Marchal JA. The FASEB Journal. 2019;33(7):8363-8374. https://doi.org/10.1096/fj.201802009RR

Insight into the biological pathways underlying fibromyalgia by a proteomic approach /2018/ Ramírez-Tejero JA, Martínez-Lara E, Rus A, Camacho MV, del Moral ML, Siles E. J Proteomics. 2018;186:47-55. https://doi.org/10.1016/j.jprot.2018.07.009

Hypoxia modulates the antioxidant effect of hydroxytyrosol in MCF-7 breast cancer cells /2018/ Calahorra J, Martínez-Lara E, De Dios C, Siles E. PLoS One. 2018;13(9):e0203892. https://doi.org/10.1371/journal.pone.0203892

Melatonin influences NO/NOS pathway and reduces oxidative and nitrosative stress in a model of hypoxic-ischemic brain damage |2017| Blanco S, Hernández R, Franchelli G, Ramos-Álvarez MM, Peinado MÁ. Nitric Oxide 2017;62:32-43. http://dx.doi.org/10.1016/j.niox.2016.12.001

Comparative proteomic study of early hypoxic response in the cerebral cortex of rats submitted to two different hypoxic models |2017| Ovelleiro D, Blanco S, Hernández R, Peinado MÁ. Proteomics Clin Appl 2017;11(11-12). https://doi: 10.1002/prca.201700058

MCPH1, mutated in primary microcephaly, is required for efficient chromosome alignment during mitosis |2017| Arroyo M, Kuriyama R, Trimborn M, Keifenheim D, Cañuelo A, Sánchez A, Clarke DJ, Marchal JA. Sci Rep. 2017;7(1):13019. 10.1038/s41598-017-12793-7

Effectiveness of Global Postural Reeducation for Treatment of Spinal Disorders: A Meta-analysis |2017| Lomas-Vega R, Garrido-Jaut MV, Rus A, del Pino-Casado R. Am J Phys Med Rehabil. 2017;96(2):124-130. https://doi.org/10.1097/PHM.0000000000000575

Experienced versus Inexperienced Interexaminer Reliability on Location and Classification of Myofascial Trigger Point Palpation to Diagnose Lateral Epicondylalgia: An Observational Cross-Sectional Study |2016| Mora-Relucio R, Núñez-Nagy S, Gallego-Izquierdo T, Rus A, Plaza-Manzano G, Romero-Franco N, Ferragut-Garcías A, Pecos-Martín D. Evid Based Complement Alternat Med. 2016;2016:6059719. https://doi.org/10.1155/2016/6059719

Hydroxytyrosol decreases the oxidative and nitrosative stress levels and promotes angiogenesis through HIF-1 independent mechanisms in renal hypoxic cells /2016/ Martínez-Lara E, Peña A, Calahorra J, Cañuelo A, Siles E. Food Funct. 2016;7(1):540-548. https://doi.org/10.1039/c5fo00928f

Temporal profiles of blood pressure, circulating nitric oxide, and adrenomedullin as predictors of clinical outcome in acute ischemic stroke patients /2016/ Serrano-Ponz M, Rodrigo-Gasqué C, Siles E, Martínez-Lara E, Ochoa-Callejero L, Martínez A. Mol Med Rep. 2016;13(5):3724-3734. https://doi.org/10.3892/mmr.2016.5001

Gene expression profiling to investigate tyrosol-induced lifespan extension in Caenorhabditis elegans |2016| Cañuelo A, Esteban FJ, Peragón J. Eur J Nutr. 2016;55(2):639-650. 10.1007/s00394-015-0884-3

Effects of a human milk oligosaccharide, 2′-fucosyllactose, on hippocampal long-term potentiation and learning capabilities in rodents |2015| Vázquez E, Barranco A, Ramírez M, Gruart A, Delgado-García JM, Martínez-Lara E, Blanco S, Martín MJ, Castanys E, Buck R, Prieto P, Rueda R. J Nutr Biochem. 2015;26(5):455-465. https://doi.org/10.1016/j.jnutbio.2014.11.016

Study of tamoxifen urinary metabolites in rat by ultra-high-performance liquid chromatography time-of-flight mass spectrometry /2015/ Domínguez-Romero JC, García-Reyes JF, Beneito-Cambra M, Martínez-Romero R, Martínez-Lara E, del Moral-Leal ML, Molina-Díaz A. Biomed Chromatogr. 2015;29(8):1220-1228. https://doi.org/10.1002/bmc.341

Shorter telomere length predicts poorer immunological recovery in virologically suppressed HIV-1-infected patients treated with combined antiretroviral therapy /2015/ Blanco JR, Jarrin I, Martínez A, Siles E, Larrayoz IM, Cañuelo A, Gutiérrez F, González-García J, Vidal F, Moreno S; CoRIS-Biobanco. J Acquir Immune Defic Syndr. 2015;68(1):21-29. https://doi.org/10.1097/QAI.0000000000000398

Proteomic characterization of nitrated cell targets after hypobaric hypoxia and reoxygenation in rat brain |2014| Peinado MÁ, Hernández R, Peragón J, Ovelleiro D, Pedrosa JÁ, Blanco S. J Proteomics. 2014;109:309-321. http://dx.doi.org/10.1016/j.jprot.2014.07.015

Oral quercetin supplementation hampers skeletal muscle adaptations in response to exercise training |2014| Casuso RA, Martínez-López EJ, Nordsborg NB, Hita-Contreras F, Martínez-Romero R, Cañuelo A, Martínez-Amat A. Scand J Med Sci Sports. 2014;24(6):920-792. https://doi.org/10.1111/sms.12136

Dexamethasone upregulates Nox1 expression in vascular smooth muscle cells |2014| Siuda D, Tobias S, Rus A, Xia N, Förstermann U, Li H. Pharmacology. 2014;94(1-2):13-20. https://doi.org/10.1159/000365932

Interaction between PARP-1 and HIF-2α in the hypoxic response /2014/ Gonzalez-Flores A, Aguilar-Quesada R, Siles E, Pozo S, Rodríguez-Lara MI, López-Jiménez L, López-Rodríguez M, Peralta-Leal A, Villar D, Martín-Oliva D, del Peso L, Berra E, Oliver FJ. Oncogene. 2014;33(7):891-898. https://doi.org/10.1038/onc.2013.9

The combination of oral quercetin supplementation and exercise prevents brain mitochondrial biogenesis |2014| Casuso RA, Martínez-López EJ, Hita-Contreras F, Camiletti-Moiron D, Martínez-Romero R, Cañuelo A, Martínez-Amat A. Genes Nutr. 2014;9(5):420. 10.1007/s12263-014-0420-8

Hypobaric hypoxia and reoxygenation induce proteomic profile changes in the rat brain cortex |2013| Hernández R, Blanco S, Peragón J, Pedrosa JÁ, Peinado MÁ. Neuromolecular Med. 2013;15(1):82-94. https://doi.org/10.1007/s12017-012-8197-7

Proteomics analysis in Caenorhabditis elegans to elucidate the response induced by tyrosol, an olive phenol that stimulates longevity and stress resistance |2013| Cañuelo A, Peragón J. Proteomics. 2013;13(20):3064-3075. https://doi.org/10.1002/pmic.201200579

Combined data mining strategy for the systematic identification of sport drug metabolites in urine by liquid chromatography time-of-flight mass spectrometry /2013/ Domínguez-Romero JC, García-Reyes JF, Martínez-Romero R, Martínez-Lara E, del Moral ML, Molina-Díaz A. Anal Chim Acta 2013;761:1-10. https://doi.org/10.1016/j.aca.2012.11.049

Detection of main urinary metabolites of b2-agonists clenbuterol; salbutamol and terbutaline by liquid chromatography high resolution mass spectrometry /2013/ Domínguez-Romero JC, García-Reyes JF, Martínez-Romero R, Martínez-Lara E, del Moral ML, Molina-Díaz A. J Chromatogr B. 2013;923-924:128-135. https://doi.org/10.1016/j.jchromb.2013.02.008

The hypoxic preconditioning agent deferoxamine induces poly(ADP-ribose) polymerase-1-dependent inhibition of the mitochondrial respiratory chain /2012/ Cañuelo A, Martínez-Romero R, Martínez-Lara E, Sánchez-Alcázar JA, Siles E. Mol Cell Biochem. 2012;363(1-2):101-108. https://doi.org/10.1007/s11010-011-1162-1

ROS-induced DNA damage and PARP-1 are required for optimal induction of starvation-induced autophagy /2012/ Rodríguez-Vargas JM, Ruiz-Magaña MJ, Ruiz-Ruiz C, Majuelos-Melguizo J, Peralta-Leal A, Rodríguez MI, Muñoz-Gámez JA, de Almodóvar MR, Siles E, Rivas AL, Jäättela M, Oliver FJ. Cell Res. 2012;22(7):1181-1198. https://doi.org/10.1038/cr.2012.70

Tyrosol, a main phenol present in extra virgin olive oil, increases lifespan and stress resistance in Caenorhabditis elegans /2012/ Cañuelo A, Gilbert-López B, Pacheco-Liñán P, Martínez-Lara E, Siles E, Miranda-Vizuete A. Mech Ageing Dev. 2012;133(8):563-574. https://doi.org/10.1016/j.mad.2012.07.004

Nitric oxide modulates hypoxia-inducible factor-1 and poly(ADP-ribose) polymerase-1 cross talk in response to hypobaric hypoxia /2012/ Martínez-Romero R, Cañuelo A, Siles E, Oliver FJ, Martínez-Lara E. J Appl Physiol. 2012;112(5):816-823. https://doi.org/10.1152/japplphysiol.00898.2011

Is endothelial-nitric-oxide-synthase-derived nitric oxide involved in cardiac hypoxia/reoxygenation-related damage? |2011| Rus A, Peinado MÁ, Blanco S, del Moral ML. J Biosci. 2011;36(1):69-78. 10.1007/s12038-011-9006-4

Study of the nitric oxide system in the rat cerebellum during aging |2011| Blanco S, Molina FJ, Castro L, del Moral ML, Hernández R, Jiménez A, Rus A, Martínez-Lara E, Siles E, Peinado MÁ. BMC Neurosci. 2010;11:78. https://doi.org/10.1186/1471-2202-11-78

Phenylalanine ammonia-lyase and phenolic compounds in leaves and fruits of Olea europaea L. cv. Picual during ripening |2009| Ortega-García F, Blanco S, Peinado MÁ, Peragón J. J Sci Food Agric. 2009;89:398-406. 10.1002/jsfa.3458

Poly(ADP-ribose) polymerase-1 modulation of in vivo response of brain hypoxia-inducible factor-1 to hypoxia/reoxygenation is mediated by nitric oxide and factor inhibiting HIF /2009/ Martínez-Romero R, Cañuelo A, Martínez-Lara E, Javier Oliver F, Cárdenas S, Siles E. J Neurochem. 2009;111(1):150-159. https://doi.org/10.1111/j.1471-4159.2009.06307.x

Polyphenol oxidase and its relationship with oleuropein concentration in fruits and leaves of olive (Olea europaea) cv. ‘Picual’ trees during fruit ripening |2008| Ortega-García F, Blanco S, Peinado MÁ, Peragón J. Tree Physiol. 2008;28(1):45-54.

PARP-1 modulates deferoxamine-induced HIF-1alpha accumulation through the regulation of nitric oxide and oxidative stress /2008/ Martínez-Romero R, Martínez-Lara E, Aguilar-Quesada R, Peralta A, Oliver FJ, Siles E. J Cell Biochem. 2008;104(6):2248-2260. https://doi.org/10.1002/jcb.21781

Age modulates the nitric oxide system response in the ischemic cerebellum |2007| Blanco S, Castro L, Hernández R, del Moral ML, Pedrosa JA, Martínez-Lara E, Siles E, Peinado MÁ. Brain Res. 2007;1157:66-73. https://doi.org/10.1016/j.brainres.2007.01.141

Age and sex-related serum changes in nitric oxide: correlations with serological markers /2007/ Peinado MÁ, López-Ramos JC, Camacho MV, Molina FJ, Martínez-Romero R, Hernández R, Siles E, Martínez-Lara E, del Moral ML, Pedrosa JA, Gásso M. Int J Cardiol. 2007;121(1):88-90. https://doi.org/10.1016/j.ijcard.2006.08.032

The nitric oxide system response to hypoxia/reoxygenation in the aged cerebral cortex /2007/ Cañuelo A, Siles E, Martínez-Romero R, Peinado MÁ, Martínez-Lara E. Exp Gerontol. 2007;42(12):1137-1145. https://doi.org/10.1016/j.exger.2007.09.006

Aging affects but does not eliminate the enzymatic antioxidative response to hypoxia/reoxygenation in cerebral cortex /2006/ Martínez-Romero R, Cañuelo A, Martínez-Lara E, Hernández R, del Moral ML, Pedrosa JA, Peinado MÁ, Siles E. Exp Gerontol. 2006;41(1):25-31. https://doi.org/10.1016/j.exger.2005.09.009

Steatosis recovery after treatment with a balanced sunflower or olive oil-based diet: involvement of perisinusoidal stellate cells |2005| Hernández R, Martínez-Lara E, Cañuelo A, del Moral ML, Blanco S, Siles E, Jiménez A, Pedrosa JA, Peinado MÁ. World J Gastroenterol. 2005;11(47):7480-7485.

Colorimetric quantification and in situ detection of collagen |2005| Esteban FJ, del Moral ML, Sánchez-López AM, Blanco S, Jiménez A, Hernández R, Pedrosa JA, Peinado MÁ. J Biol Educ. 2005;39(4):183-186.

Constitutive nitric oxide synthases are responsible for the nitric oxide production in the ischemic aged cerebral cortex |2005| Martínez-Lara E, Cañuelo AR, Siles E, Hernández R, del Moral ML, Blanco S, Pedrosa JA, Rodrigo J, Peinado MÁ. Brain Res. 2005;1054(1):88-94. 10.1016/j.brainres.2005.06.060

PARP-1-dependent 3-nitrotyrosine protein modification after DNA damage /2005/ Siles E, Martínez-Lara E, Núñez MI, Muñoz-Gámez JA, Martín-Oliva D, Valenzuela MT, Peinado MÁ, Ruiz de Almodóvar JM, Javier Oliver F. J Cell Biochem. 2005;96(4):709-715. https://doi.org/10.1002/jcb.20570

Evidence of a decrease in nitric oxide-storage molecules following acute hypoxia and/or hypobaria, by means of chemiluminescence analysis /2005/ López-Ramos JC, Martínez-Romero R, Molina F, Cañuelo A, Martínez-Lara E, Siles E, Peinado MÁ. Nitric Oxide. 2005;13(1):62-67. https://doi.org/10.1016/j.niox.2005.05.003

Serine dehydratase expression decreases in rat livers injured by chronic thioacetamide ingestion /2005/ López-Flores I, Barroso JB, Valderrama R, Esteban FJ, Martínez-Lara E, Luque F, Peinado MÁ, Ogawa H, Lupiáñez JA, Peragón J. Mol Cell Biochem. 268:33-43. https://doi.org/10.1007/s11010-005-2995-2

Immunohistochemistry of neuronal nitric oxide synthase and protein nitration in the striatum of the aged rat |2004| del Moral ML, Esteban FJ, Hernández R, Blanco S, Molina FJ, Martínez-Lara E, Siles E, Viedma G, Ruiz A, Pedrosa JA, Peinado MÁ. Microsc Res Tech. 2004;64(4):304-311. 10.1002/jemt.20081

Upregulation of endothelial nitric oxide synthase maintains nitric oxide production in the cerebellum of thioacetamide cirrhotic rats |2004| Hernández R, Martínez-Lara E, del Moral ML, Blanco S, Cañuelo A, Siles E, Esteban FJ, Pedrosa JA, Peinado MÁ. Neuroscience. 2004;126(4):879-87. 10.1016/j.neuroscience.2004.04.010

Glutathione S-transferase isoenzymatic response to aging in rat cerebral cortex and cerebellum |2003| Martínez-Lara E, Siles E, Hernández R, Cañuelo AR, del Moral ML, Jiménez A, Blanco S, López-Ramos JC, Esteban FJ, Pedrosa JA, Peinado MÁ. Neurobiol Aging. 2003;24(3):501-509.

Reactive oxygen species mediate the down-regulation of mitochondrial transcripts and proteins by tumour necrosis factor-alpha in L929 cells /2003/ Sánchez-Alcázar JA, Schneider E, Hernández-Muñoz I, Ruiz-Cabello J, Siles-Rivas E, de la Torre P, Bornstein B, Brea G, Arenas J, Garesse R, Solís-Herruzo JA, Knox AJ, Navas P. Biochem J. 2003;370(Pt 2):609-619. https://doi.org/10.1042/BJ20021623

Age-related changes of the nitric oxide system in the rat brain |2002| Siles E, Martínez-Lara E, Cañuelo A, Sánchez M, Hernández R, López-Ramos JC, del Moral ML, Esteban FJ, Blanco S, Pedrosa JA, Rodrigo J, Peinado MÁ. Brain Res. 2002;956(2):385-392.

Evidence from heterologous expression of glutathione S-transferases A and A1 of the plaice (Pleuronectes platessa) that their endogenous role is in detoxification of lipid peroxidation products /2002/ Martínez-Lara E, Leaver M, George SG. Mar Environ Res. 2002;54:263-266. https://doi.org/10.1016/S0141-1136(02)00188-5

Immunohistochemical localisation of neuronal nitric oxide synthase in the rainbow trout kidney |2001| Jiménez A, Esteban FJ, Sánchez-López AM, Pedrosa JA, del Moral ML, Hernández R, Blanco S, Barroso JB, Rodrigo J, Peinado MÁ. J Chem Neuroanat. 2001;21(4):289-294.

Aging and neurodegeneration: molecular and cellular bases |2000| Peinado MÁ, del Moral ML, Esteban FJ, Martínez-Lara E, Siles E, Jiménez A, Hernández-Cobo R, Blanco S, Rodrigo J, Pedrosa JA. Rev Neurol. 2000;31(11):1054-1065.

Tumor necrosis factor-alpha increases the steady-state reduction of cytochrome b of the mitochondrial respiratory chain in metabolically inhibited L929 cells /2000/ Sánchez-Alcázar JA, Schneider E, Martínez MA, Carmona P, Hernández-Muñoz I, Siles E, De La Torre P, Ruiz-Cabello J, García I, Solis-Herruzo JA. J Biol Chem. 2000;275(18):13353-13361. https://doi.org/10.1074/jbc.275.18.13353

Molecular and kinetic characterization and cell-type localisation of inducible nitric oxide synthase in fish /2000/ Barroso JB, Carreras A, Esteban FJ, Peinado MÁ, Martínez-Lara E, Valderrama R, Jiménez A, Rodrigo J, Lupiáñez JA. Am J Physiol Regul Integr Comp Physiol. 2000;279:650-656. https://doi.org/10.1152/ajpregu.2000.279.2.R650

Levels of cellular glutathione and metallothionein affect the toxicity of oxidative stressors in an established carp cell line /2000/ Wright J, George S, Martínez-Lara E, Carpene E, Kindt M. Mar Environ Res. 2000;50(1-5):503-508. https://doi.org/10.1016/S0141-1136(00)00125-2

DNA damage and prediction of radiation response in lymphocytes and epidermal skin human cells /1998/ Núñez MI, Guerrero MR, López E, del Moral MR, Valenzuela MT, Siles E, Villalobos M, Pedraza V, Peacock JH, Ruiz de Almodóvar JM. Int J Cancer. 1998;76(3):354-361. https://doi.org/10.1002/(SICI)1097-0215(19980504)76:3<354::AID-IJC12>3.0.CO;2-B

Apoptosis after gamma irradiation. Is it an important cell death modality? /1998/ Siles E, Villalobos M, Jones L, Guerrero R, Eady JJ, Valenzuela MT, Núñez MI, McMillan TJ, Ruiz de Almodóvar JM. Br J Cancer. 1998;78(12):1594-1599. https://doi.org/10.1038/bjc.1998.728

A comparison of p53 and p16 expression in human tumor cells treated with hyperthermia or ionizing radiation /1997/ Valenzuela MT, Núñez MI, Villalobos M, Siles E, McMillan TJ, Pedraza V, Ruiz de Almodóvar JM. Int J Cancer. 1997;72(2):307-312. https://doi.org/10.1002/(sici)1097-0215(19970717)72:2<307::aid-ijc18>3.0.co;2-c

Tumor necrosis factor-alpha increases ATP content in metabolically inhibited L929 cells preceding cell death /1997/ Sánchez-Alcázar JA, Ruiz-Cabello J, Hernández-Muñoz I, Pobre PS, de la Torre P, Siles-Rivas E, García I, Kaplan O, Muñoz-Yagüe MT, Solís-Herruzo JA. J Biol Chem. 1997;272(48):30167-30177. https://doi.org/10.1074/jbc.272.48.30167

Antioxidant and detoxifying fish enzymes as biomarkers of river pollution /1997/ Lenartova V, Holovska K, Pedrajas JR, Martínez-Lara E, Peinado J, López-Barea J, Rosival I, Kosuth P. Biomarkers 1997;2:247-252. https://doi.org/10.1080/135475097231625

Purification and characterization of multiple glutathione transferase isoenzymes from grey mullet liver /1997/ Martínez-Lara E, George SG, López-Barea J, Bárcena JA. Cell Mol Life Sci. 1997;53:759-768. https://doi.org/10.1007/s000180050096

Glutathione S-transferase isoenzyme patterns in the gilthead seabream (Sparus aurata) exposed to environmental contaminants /1996/ Martínez-Lara E, Toribio F, López-Barea J, Bárcena JA. Comp Biochem Physiol. 1996;113C(2):215-220. https://doi.org/10.1016/0742-8413(95)02090-X

Radiosensitivity of human breast cancer cell lines of different hormonal responsiveness. Modulatory effects of oestradiol /1996/ Villalobos M, Becerra D, Núñez MI, Valenzuela MT, Siles E, Olea N, Pedraza V, Ruiz de Almodóvar JM. Int J Radiat Biol. 1996;70(2):161-169. https://doi.org/10.1080/095530096145157

Relationship between p53 status and radiosensitivity in human tumour cell lines /1996/ Siles E, Villalobos M, Valenzuela MT, Núñez MI, Gordon A, McMillan TJ, Pedraza V, Ruiz de Almodóvar JM. Br J Cancer. 1996;73(5):581-588. https://doi.org/10.1038/bjc.1996.101

Changes in GST-isoenzyme pattern of some organs of sheep exposed to different levels of pollution /1996/ Lenartova V, Holovska K, Martínez-Lara E, Bárcena JA, López-Barea J, Rosival I. Comp Biochem Physiol. 1996;114C(2):153- 158. https://doi.org/10.1016/0742-8413(96)00025-4

Methods for purification of glutathione peroxidase and related enzymes /1996/ Toribio F, Martínez-Lara E, Pascual P, López-Barea J. J Chromatogr B. 1996;684:77-97. https://doi.org/10.1016/0378-4347(95)00504-8

Relationship between doxorubicin cell sensitivity, drug-induced DNA double-strand breaks, glutathione content and P-glycoprotein in mammalian tumor cells /1995/ Valenzuela MT, Núñez MI, Villalobos M, Siles E, Olea N, Pedraza V, McMillan TJ, Ruiz de Almodóvar JM. Anticancer Drugs. 1995;6(6):749-757. https://doi.org/10.1097/00001813-199512000-00006

Biochemical and genetics indices of marine pollution in Spanish littoral /1993/ Rodríguez-Ariza A, Martínez-Lara E, Pascual P, Pedrajas JR, Abril N, Toribio F, Dorado G, Bárcena JA, Peinado J, Pueyo C, López-Barea J, Bárcena JA. Sci Total Environ. 1993;134(S1):109-116. https://doi.org/10.1016/S0048-9697(05)80009-9

A direct assay of glutathione peroxidase activity using high perfomance capillary electrophoresis /1992/ Pascual P, Martínez-Lara E, Bárcena JA, López-Barea J, Toribio F. J Chromatogr Biomed Appl. 1992;581(1):49-56. https://doi.org/10.1016/0378-4347(92)80446-W

A rapid method for the quantification of glutathione transferase isoenzymes in crude extracts /1992/ Martínez-Lara E, Pascual P, Toribio F, López-Barea J, Bárcena JA. J Chromatogr. 1992;609(1):141-146. https://doi.org/10.1016/0021-9673(92)80157-P

HPLC isoenzyme patterns of glutathione transferase from marine fishes with different levels of pollution /1991/ Pascual P, Martínez-Lara E, Toribio F, López-Barea J, Bárcena JA. Biochemical Society Transactions 1991;19(3):203S. https://doi.org/10.1042/bst019302s